The invention discloses a preparation process for puerarin tramadol, which belongs to the technical field of biochemistry. The preparation process comprises the following seven procedures: hydrogenation reduction of a compound a; esterification of a compound b and acetic anhydride; a reaction of a compound c with p-methoxyphenylacetyl chloride; a reduction reaction of a compound d; a reaction of a compound e with DMFDMA; reduction of a compound f into puerarin; and synthesis of puerarin tramadol. The novel compound puerarin tramadol is synthesized in the invention; and the novel compound has same pain easing effect as tramadol, fundamentally reduces the usage amount of tramadol, decreases tolerance and addiction of tramadol, alleviates side effect of tramadol on a digestive system and a circulatory system to a certain extent and controls adverse reaction, thereby realizing safer and more effective clinical medication.