The invention discloses a multi-direction space energy particle detection device by using grid regulation, which comprises a collimator, a modulated coded grid, a semiconductor sensor, an electronics section and a housing, wherein the collimator is used for limiting the space detection range of the energy particles; the modulated coded grid is used for limiting the flux of particles in different directions; the semiconductor sensor is used for detecting the energy of the energy particles; the semiconductor sensor is a pixel-type solid sensor, and when space particles enter the semiconductor sensor, due to lost energy, electrical signal pulses are excited at electrodes at two sides; and the electronics section is used for processing electrical signals provided by the semiconductor sensor to provide the particle kinds and the energy for reflecting the space particle energy.