The invention belongs to the vehicle alarm device technology field and particularly relates to a waterproof vehicle audio alarm device having a self protection circuit. The waterproof vehicle audio alarm device comprises a high voltage protection circuit, an intermittent tone generation circuit, a power amplification and output current circuit and a loudspeaker, wherein an upper wall of a sound film of the loudspeaker is provided with a waterproof ventilation film, the loudspeaker is connected with a positive electrode end of the high voltage protection circuit, the other end of the loudspeaker is connected with the power amplification and output current circuit, the power amplification and output current circuit is connected with the intermittent tone generation circuit, the high voltage protection circuit comprises an electric signal anti-interference network module, an emitter follower module and a protection circuit module which are sequentially connected in series and further comprises a power source anti-interference network module connected with the emitter follower module, the power source anti-interference network module is connected with the intermittent tone generation circuit, the protection circuit module and the loudspeaker, and the electric signal anti-interference network module is further provided with a protection diode. The waterproof vehicle audio alarm device has the high voltage protection function and further has properties of good waterproof performance and long service life.