The invention relates to a clamp, in particular to a pipe fitting pillow structure fixing clamp, and belongs to the technical field of clamp devices. The pipe fitting pillow structure fixing clamp comprises a base plate. The front position and the rear position of the base plate are connected with a base and a front baffle through bolts. Two slide rail bases horizontally symmetrical are fixed to the base. A slide rail is arranged on each slide rail base. The two slide rails of the two slide rail bases are connected with a slide base together. A pillow positioning column fixing base is fixed to the slide base. A plurality of pillow positioning columns are arranged at the front end of the pillow positioning column fixing base. A clamping cylinder base is fixed to the base, a clamping cylinder is fixed to the clamping cylinder base, the front end of a cylinder rod of the clamping cylinder is connected with a slide base push plate, and the slide base push plate is fixed to the rear end of the pillow positioning column fixing base. The pipe fitting pillow structure fixing clamp is simple, compact and reasonable in structure, stable and reliable in work and low in cost; pipe fittings of a pillow structure can be stably clamped, work efficiency is improved, and the pipe fittings are prevented from damage.