The invention relates to the field of sludge treatment, and in particular to a sludge vitrifaction curing treatment process which comprises the following steps: dehydrating and drying sludge in sequence so as to reduce the water content of sludge; crushing and grinding the dried sludge till the crushed sludge can pass through the 100-mesh screen; sufficiently mixing the grinded sludge with silicate powder according to a mass ratio of 1:0.5 at the temperature of 25-50 DEG C at the rotation speed of 2400 r/min, so as to obtain mixed powder; performing high-temperature calcination on the mixed powder at 1700 DEG C to completely carbonize and decompose organisms in the sludge, and finally molding the residual inorganic substances into glass solid granules. By the adoption of the sludge vitrifaction curing treatment process, harmful substances such as heavy metals and arsenide which are hard to carbonize or decompose can be fixed in the glass solid granules. The result of a toxicity leaching test on a glass solid granule sample according to GB5805.3-2007 shows that the national environment-friendly requirements can be met, and the glass solid granule sample can be directly buried. The process provided by the invention requires lowly on sources of sludge and components of pollutant in the sludge, and is applicable to various types of sludge; harmlessness, reduction and stabilization treatment on sludge can be achieved.