The invention discloses specialty compound fertilizer for tobacco for improving the solubility and utilization of fertilizer. Nutrient contents of nitrogen phosphorus and potassium in the compound fertilizer is 1:(1-1.5):(2-3). The preparation method comprises the steps of uniformly mixing all materials and then performing granulation according to the traditional method. The compound fertilizer improves the total nutrient contents of nitrogen phosphorus and potassium by increasing the ratio of a filler in the compound fertilizer, can obviously improve the solubility and utilization of the fertilizer, ensures that nutrient supplied is matched with nutrient requirements in tobacco plant growth duration, promotes the growth and development of tobacco, and can obviously improve the yield and quality of tobacco.