The invention discloses a beer barrel cleaning valve which comprises a valve body and a valve rod. The valve body is provided with a cleaning medium channel, a first seal ring is installed between the valve body and the valve rod, the valve body is provided with an outlet, and the valve rod is provided with a central through hole. The top of the valve rod penetrates the valve body, a cylinder barrel is fixed to the bottom of the valve body, the lower end of the valve rod penetrates the cylinder barrel and is communicated with the medium channel, and a piston positioned in the cylinder barrel is fixed to the valve rod. A second seal ring is arranged between the bottom of the cylinder barrel and the valve rod, a downlink chamber is formed between the first seal ring and the piston, and an uplink chamber is formed between the piston and the second seal ring. The cylinder barrel is provided with an uplink air inlet and a downlink air outlet, and the valve rod is vertically slidably installed on a support and driven by a valve body lifting power device. The valve body and the valve rod of the cleaning valve rise to be matched with beer barrels, on-line cleaning of the beer barrels is achieved on a beer barrel filling production line, and filling efficiency and sanitary conditions of the beer barrels are improved.