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发明公开
CN105646217A 正丁基丙二酸二乙酯的制备方法 无效 - 驳回

正丁基丙二酸二乙酯的制备方法
摘要：
本发明公开了一种正丁基丙二酸二乙酯的制备方法，包括以下步骤：1)乙醇和钠反应生成乙醇钠；2)向步骤1)得到的乙醇钠中加入丙二酸二乙酯，生成丙二酸二乙酯钠盐；3)向步骤2)得到的丙二酸二乙酯钠盐中加入溴丁烷，反应生成正丁基丙二酸二乙酯。本发明以乙醇、钠、丙二酸二乙酯和溴丁烷为原料，无需采用催化剂，制备得到的正丁基丙二酸二乙酯收率高、纯度高，符合药物质量标准，同时降低了制作成本。
摘要（英）：

The invention discloses a preparation method of diethyl n-butylmalonate. The preparation method comprises following steps as follows: 1), ethanol and sodium react to generate sodium ethoxide; 2), diethyl malonate is added to sodium ethoxide obtained in the step 1), and diethyl malonate sodium salt is generated; 3), bromobutane is added to the diethyl malonate sodium salt obtained in the step 2), and diethyl n-butylmalonate is generated through reaction. According to the preparation method of diethyl n-butylmalonate, ethanol, sodium, diethyl malonate and bromobutane are taken as raw materials, a catalyst is not required, prepared diethyl n-butylmalonate has high yield and high purity and meets the drug quality standard, and meanwhile, the preparation cost is reduced.

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