The invention provides a main profile structure with co-extrusion adhesive tape. The structure comprises a macromolecule heat-preservation thermal-insulation profile with a glass installation cavity, the co-extrusion adhesive tape is integrally made by a glass notch formed in the portion, directly facing the upper portion, of the bottom of the glass installation cavity of the macromolecule heat-preservation thermal-insulation profile, and under extrusion and compression of glass, the co-extrusion adhesive tape divides the cavity between the macromolecule heat-preservation thermal-insulation profile and the glass notch into two parts; the co-extrusion adhesive tape is formed by an arc-shaped injecting locating plate on one side and connected colloid of which the upper end plane tightly abuts against the indoor side notch of the glass, and sealant is formed by conducting sealing treatment on the co-extrusion adhesive tape and the overlap joint portion of the glass on the indoor side. The main profile structure with the co-extrusion adhesive tape has the advantages of being simple in structure, convenient and reliable to use, capable of ensuring the sealing property and safety of doors and windows and the like.