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发明公开
CN105658660A PCV2ORF2蛋白变体和由其组成的病毒样颗粒 审中-实审

PCV2ORF2蛋白变体和由其组成的病毒样颗粒
摘要：
公开了用于控制不同PCV2亚型的PCV2感染的疫苗接种方法。具体地，将PCV2亚型B(PCV2B)ORF2蛋白或包含PCV2B ORF2蛋白的免疫原性组合物用在以下方法中：治疗或预防相同PCV2B和/或不同亚型的PCV2的感染；减轻、预防或治疗由相同PCV2B或不同亚型的PCV2的感染造成的临床征象；和/或预防或治疗由相同PCV2B和/或不同亚型的PCV2造成的疾病的感染。本发明尤其涉及PCV2亚型B(PCV2B)ORF2蛋白，其特征在于，它们在BC环中含有至少一个突变，使得表达的蛋白优选地与不含有这样的突变的PCV2 ORF2蛋白相比以更高的量表达。
摘要（英）：

Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.

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