The invention belongs to the technical field of packaging, and relates to an automatic packaging machine for paper packaging of medium and large products. The automatic packaging machine for paper packaging of the medium and large products comprises a rotating device, a moving device, a horizontal folding operation arm and a vertical folding operation arm, wherein the moving device is arranged above the rotating device in a straddling manner; the horizontal folding operation arm and the vertical folding operation arm are arranged on the moving device; the rotating device comprises a horizontal base and a rotating table pivotally connected to the upper part of the base; the moving device comprises two pairs of supports, two X moving guide tracks and a Y moving rack; the two pairs of supports are arranged on the periphery of the base; each X moving guide track is arranged on the corresponding pair of supports in a straddling manner; the Y moving rack is movably arranged between the two X moving guide tracks; and the horizontal folding operation arm and the vertical folding operation arm are movably arranged on the Y moving rack respectively. A packaged article rotates with the aid of the rotating table, and folding and gluing of packaging paper are realized by the operation arms. The automatic packaging machine is relatively suitable for packaging large products, and is safe in use and convenient to control, and labor is librated.