The embodiment of the invention provides an intelligent vehicle cruise control method and device based on a real-time road condition to solve the problem that in the prior art, an oil saving effect is not ideal when a vehicle cruises under a slope road condition. The method includes the steps that for the vehicle in a cruise mode, position information of the vehicle and road condition information are obtained, wherein the road condition information comprises slope information; a travel mode of the vehicle is confirmed according to the obtained position information and road condition information, wherein the travel mode is a before-uphill mode or a before-downhill mode; and when it is confirmed that the vehicle is in the before-uphill mode or the before-downhill mode, the target cruise speed of the vehicle is correspondingly increased or decreased.