The invention discloses a cleaning and filling machine which comprises a barrel feeding station, a cleaning station, a filling station, a barrel discharging station and a conveying mechanism. The barrel feeding station, the cleaning station, the filling station and the barrel discharging station are sequentially arranged in the first direction. The conveying mechanism comprises a lifting frame, a lifting device for driving the lifting frame to ascend and descend, a bearing frame which is movably mounted on the lifting frame and can move relative to the lifting frame in the first direction and a drive device used for driving the bearing frame to move forwards and backwards in the first direction. The bearing frame is used for bearing barrel bodies and comprises two bearing seats oppositely arranged in a spaced manner. By the adoption of the cleaning and filling machine, participation of operators can be reduced, the labor intensity of the operators can be relieved, and production efficiency can be improved as well.