The invention discloses a method for processing high-acid heavy crude oil processing wastewater. The method comprises the following step: high-acid heavy crude oil processing wastewater is contacted with a catalyst, wherein the catalyst contains an ozone catalytic oxidation catalyst. The ozone catalytic oxidation catalyst comprises a carrier and active components and auxiliaries which are loaded on the carrier. The carrier contains gamma-alumina. The active component elements contain Fe, Mn, Cu and Co. The auxiliary elements contain Ce and Mg. The method for processing high-acid heavy crude oil processing wastewater is low-priced, has simple process and is green and environmentally friendly. In addition, the catalyst used in the method has long service life, high catalytic activity and stable catalytic performance.