The invention discloses a packing method of a catalyst for processing high-acid heavy crude oil processing wastewater. The method comprises the following step: along the material flow direction, a catalytic reactor is successively filled with an assistant catalyst A, an ozone catalytic oxidation catalyst and an assistant catalyst B, wherein the ozone catalytic oxidation catalyst comprises a carrier and active components and auxiliaries which are loaded on the carrier. The carrier contains gamma-alumina. The active component elements contain Fe, Mn, Cu and Co. The auxiliary elements contain Ce and Mg. By the packing method of the catalyst capable of maintain stable physical and chemical performance for a long time and for processing high-acid heavy crude oil processing wastewater, COD cr value of wastewater can be remarkably reduced. In addition, by the above packing method, the ozone catalytic oxidation catalyst used has long service life and high catalytic activity.