The invention relates to an eliminating system and method for wastewater biological toxicity in an industrial park. The system comprises an adjusting tank, a micro-aerobic denitrification decarburization tank, a precipitation tank, a primary coagulative precipitation tank, a primary sand filter, a catalytic ozonation system, a suspension attachment anaerobic hydrolysis acidification tank, a biological aerated filter, a secondary coagulative precipitation tank, a secondary sand filter and an ultraviolet disinfection trench. The eliminating method comprises the steps of adjusting treatment, micro-aerobic denitrification decarburization treatment, primary coagulation precipitation, primary filtering, catalytic ozonation, anaerobic hydrolysis acidification treatment, decarburization and detoxification treatment, secondary coagulation precipitation, secondary filtering and backflow and ultraviolet disinfection treatment. The eliminating method can effectively degrade biological toxicity of wastewater in the industrial park, ensure conventional water quality detection indexes of outflow water and long-term stable standards of comprehensive biological toxicity and reduce secondary pollution of wastewater to the environment.