The invention provides a blowout prevention four-way valve. The blowout prevention four-way valve according to the invention comprises a main body, a valve core body and a regulating screw rod, wherein the main body is provided with a vertical flow passage; two lateral through holes which are horizontally opposite are formed in the two sides of the main body; the two lateral through holes are communicated with the vertical flow passage; a sealing box is connected onto the lateral through holes in a sealed way; the valve core body is glidingly arranged in the lateral through holes; a valve core body passage for clamping and installing a rod body is formed in the valve core body; a sealing element is arranged in the valve core body passage; one end, opposite to the vertical flow passage, of the sealing element is provided with a plurality of sealing bulges arranged at intervals; the regulating screw rod is arranged and connected in the sealing box in a penetrating way in a manner capable of horizontally moving; and the regulating screw rod drives and connects the valve core body. A plurality of separated sealing bulges are arranged on the sealing element; after each sealing bulge is compressed, the adaptive change can be realized in each interval belt according to the compression force condition; the radial deformation range is large; and the blowout prevention four-way valve can adapt to the sealing clamping on rod posts with different diameters.