The invention provides a stand test system for simulating automobile tire rotation and an internal pressure change, thereby realizing laboratory testing of various dynamic and static functions of a tire pressure monitoring system (TPMS). The system is composed of a rotating bearing device for simulating a tire, an inflation and deflation device, a water/gas linkage sealing device, a rotary driving device, and data acquisition processing and control system. A rotating speed of the simulated tire is adjusted by a PLC and a frequency converter. Under the circumstance that the simulated tire rotates at a high speed, air inflation and deflation inside the simulated tire are realized by using the PLC, a pressure transmitter, and a control valve; the internal pressure is controlled and adjusted accurately; and an under-pressure phenomenon of a tire, a too high pressure phenomenon of the tire and a rapid air leakage phenomenon of the tire of an automobile in a driving state can be simulated and the system is used for detecting tire pressure monitoring and alarming of the tire pressure monitoring system. The detection process can be compared repeatedly; the detection accuracy is improved and the work efficiency is enhanced; and the potential safety hazard caused by real car testing can be avoided.