The present invention discloses a coal-mine combined seismic holography prediction method, and relates to the field of the exploration method technology. The method comprises the following steps: employing a ground three-dimensional seismic exploration method to predict whether there are provided large concealed geological structures or not in the position of a minable seam, and determining concrete positions and ranges of the large concealed geological structures if there are provided large concealed geological structures; and employing a downhole slot wave exploration method to determine the concealed geological structures observed through the three-dimensional seismic exploration method in a working surface, determine the concrete positions, ranges and the areas of stress concentration; fusing a P wave and an S wave detected by the slot wave seismic exploration in the coal seam with the P wave of the three-dimensional seismic exploration and perform prediction and inversion of the lithology and the structure of the coal seam. The coal-mine combined seismic holography prediction method greatly expands the three-dimensional seismic low-frequency information, effectively inverts the prediction structure and the lithology information and improves the prediction precision so as to effectively prevent from the occurrence of the mining geology disasters, finally assist in realization of risk-free tunneling and avoid the occurrence of tunneling accidents.