The invention discloses a drone powder spraying device, comprising a hanger, a material box for containing a powder drug, a stirring discharger arranged in the material box, a control module controlling operation of the stirring discharger and a power source; the material box is connected with the hanger; the stirring discharger comprises an auger shell extending in the material box and an auger arranged in the auger shell; the auger shell is provided with a charging port and a discharging port in the upper part and lower part respectively; the auger comprises an auger shaft, a spiral plate arranged on the auger shaft for conveying the powder drug and a stirring blade for stirring. The powder drug is driven by rotation of the auger to move from bottom to top; a rotatable throwing plate is arranged under the material box; a discharging port in the upper part of the auger shell is connected to the throwing plate by a guiding pipe; the control module comprises a controller and a wireless signal receiver. The drone powder spraying device is provided with the power source per se, is capable of realizing precise and quantitative powder throwing, is simple in structure, low in manufacturing cost and good in stability and has very high promotion and application values.