The invention discloses composition with a function of clearing peculiar smell in an oral cavity. The composition is prepared from raw materials in parts by weight as follows: 1-20 parts of common lophatherum herbs, 10-50 parts of purslane, 10-40 parts of chrysanthemums, 20-40 parts of honeysuckles, 1-20 parts of lotus leaves and 1-30 parts of mint. The composition is prepared from six medicinal and edible Chinese herbs. A pharmacological experiment can inhibit multiple anaerobic bacteria and helicobacter pylori causing the peculiar smell of the oral cavity, and a clinical controlled study result further proves that the composition can relieve the subjective symptom of the patients with peculiar smell in the oral cavity.