The invention relates to a sealant-filling sealing process for a large-size flat-plate ceramic membrane filter element and belongs to the technical field of sealant-filling sealing. According to the sealant-filling sealing process, firstly, a precise cutting machine or a grinding machine is used for conducting cross section machining on a large-size flat-plate ceramic membrane body; secondly, the large-size flat-plate ceramic membrane and a water collection tank are subjected to a cementing sealing process by means of manual insertion and sealant filling through a sealant filling machine; lastly, the large-size flat-plate ceramic membrane filter element is obtained through a drying and curing process. The problems that in the current sealant-filling sealing technology, due to the fact that the sealant filling space is small, sealing by filling sealant is hard, the sealant is low in curing speed after filling, and working efficiency is low are solved, semi-automatic sealing is achieved, and the sealant-filling sealing process has the advantages that design is reasonable, running is stable, and the sealing method is simple, convenient and feasible. Through the sealant-filling sealing process, sealant-filling sealing efficiency is improved, the product bonding quality is improved, meanwhile, bonding glue can be saved, and the sealant-filling sealing process has good application prospects and broad popularization space.