The invention discloses an ordered-mesoporous Ni/Mo bimetal oxide catalyst, a preparation method and an application thereof. The catalyst is hopeful for a reduction reaction of NOx in catalytic cracking regenerated flue gas or oxidative dehydrogenation reaction of propane and belongs to the field of petrochemical engineering. The ordered-mesoporous Ni/Mo bimetal oxide is prepared with mesoporous silicon as a hard template, wherein ordered-mesoporous nickel oxide is prepared with nickel nitrate as a precursor at first, and then the ordered-mesoporous Ni/Mo bimetal oxide catalyst is prepared with the ordered-mesoporous nickel oxide as a substrate. The ordered-mesoporous Ni/Mo bimetal oxide catalyst is suitable for the oxidative dehydrogenation reaction of propane. The ordered-mesoporous bimetal oxide has ordered pores, high specific surface area, and has better oxidative dehydrogenation performance of the propane than a volume phase Ni/Mo oxide. The ordered-mesoporous nickel oxide substrate is prepared without a solvent, so that the preparation method is simple, is short in time, is high in yield, is free of consumption of solvent, such as alcohol, and has low cost.