The invention relates to the technical field of sponge processing devices, and particularly relates to a multi-knife sponge cutting machine. The multi-knife sponge cutting machine provided by the invention comprises a frame. The multi-knife sponge cutting machine is characterized by also comprising multiple portal frames, wherein the multiple portal frames are arranged at intervals; the portal frames are arranged on a frame in a parallel manner; each portal frame is provided with a layer cutting device in a sliding manner; each portal frame is provided with a lifting device which is used for adjusting the height of the corresponding layer cutting device in a lifting manner; the multi-knife sponge cutting machine also comprises a material conveying device for conveying a material to pass through the portal frames; the layer cutting devices comprise shallow layer cutting devices and deep layer cutting devices; along the movement direction of the material, the deep layer cutting devices are arranged at the downstream positions of the shallow layer cutting devices. The multi-knife sponge cutting machine provided by the invention is adjustable in cutting depth and high in production efficiency.