The invention discloses a laser rapid preparation method of an inorganic molybdenum disulfide microsphere with a fullerene like structure. The preparation method comprises the following steps: dissolving molybdenum disulfide powder into an organic solvent to form suspension liquid; radiating the suspension liquid by pulse laser so as to convert the molybdenum disulfide powder into a fullerene like structure under the effect of the organic solvent and pulse laser; after radiation, subjecting the suspension liquid to centrifugation and separation, and drying the obtained precipitate so as to obtain the inorganic molybdenum disulfide microsphere with a fullerene like structure. Molybdenum disulfide suspension liquid is directly radiated by laser beams, so that molybdenum disulfide powder in suspension liquid can obtain great energy in a very short time (nano second level), molybdenum disulfide powder is ablated and rapidly cooled (nano second level) by the solvent; and molybdenum disulfide microsphere is prepared therefore. The method has the advantages of simple operation, low cost, high product purity, and no impurity. The obtained molybdenum disulfide microsphere can reduce the friction during the friction process.