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发明授权
CN105732989B 一种紫外光3D打印用水凝胶基质的制备方法 失效 - 权利终止

一种紫外光3D打印用水凝胶基质的制备方法
摘要：
本发明涉及一种水凝胶基质的制备方法，特别是一种紫外光3D打印用水凝胶基质制备方法，属于生物材料制备技术领域。本发明是通过在透明质酸分子链上接枝烯基基团，经与双巯基聚乙二醇混合，制备得到紫外光3D打印用水凝胶基质。该水凝胶基质，充分利用巯基‑烯“点击”反应特点，在紫外光照射下迅速凝胶成型，完全克服空气中或体系中氧气的阻聚作用，大大提高3D打印效率，并且水凝胶基质生物相容性好、可完全降解被人体组织吸收。本发明制备方法简单、成本低，易工业化生产。
摘要（英）：

The invention relates to a preparation method of hydrogel substrate, in particular to a preparation method of hydrogel substrate for ultraviolet 3D printing, and belongs to the technical field of preparation of bio-materials.The hydrogel substrate for ultraviolet 3D printing is prepared through grating vinyl radicals on hyaluronic-acid molecular chains, and mixing them with dithiol polyethylene glycol.The hydrogel substrate is quickly formed under irradiation of ultraviolet light by sufficiently utilizing the 'spotting' characteristic of thiol-alkene, inhibition of oxygen in the air or system can be thoroughly overcome, and 3D printing efficiency is greatly improved.Moreover, the hydrogel substrate is good in biological compatibility, and is completely degradable and absorbable by human tissues.The preparation method is simple, low in cost and easy to realize industrial production.

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