The invention provides an air pressure type flexible array pressure sensor calibration device comprising a base and an upper cap. The upper cap is provided with an upper surface and a lower surface. The lower surface of the upper cover is provided with a groove which is upward and square, and a sealing ring is installed along the edge of the groove. The lower surface of the upper cap is fit with the base so that a sealing cavity is formed between the groove of the upper cap and the base. The upper surface of the upper cap is provided with an inflation valve, a safety air valve and a standard air pressure sensor which are respectively communicated with the sealing cavity. Each pressure sensitive point of a sensor to be measured is ensured to be affected by pressure of the same size at the same time so that calibration precision can be guaranteed, and measurement precision of the sensor to be measured in use can be enhanced; meanwhile, safety of the calibration operation process can be guaranteed through the safety air valve; the calibration process is enabled to be automatic and intelligent through external data acquisition and analysis equipment; and the calibration device is precise in structure and safe and reliable.