The invention provides a fluctuation pressurized control system and method for building curtain wall detection. The fluctuation pressurized control system comprises a blower, a pressure tank, a driving mechanism which drives the pressure tank to release pressure, and a control mechanism controlling on/off of the driving mechanism, wherein the blower communicates with the pressure tank, the driving mechanism comprises an inflator and an air pipe communicating the inflator with the pressure tank, the control mechanism comprises a single-channel thermal meter, a detection unit for detecting pressure in the pressure tank and a solenoid valve for controlling the flow direction of gases in the air pipe, and the solenoid valve and the pressure sensor are both connected with the thermal meter. Through the fluctuation pressurized control system and method for building curtain wall detection, automatic control of fluctuation pressurization is effectively realized. Operation is convenient.