The invention relates to a space-time whole process oriented line loss change analysis method. The method comprises the following steps: (1) analyzing space-time influencing factors of a line loss change, including a, a space process of the line loss change, and b, a time process of the line loss change; (2) establishing a space-time whole process oriented line loss change analysis index system; (3) collecting relevant data of indexes in the index system; and (4) calculating the contribution degree of each factor to the line loss change. The method solves the problem that the traditional method is difficult in quantitatively describing the influence of each factor on the line loss change, and can further promote the energy conservation and emission reduction work of enterprises.