The invention relates to a networked intelligent POS machine system for tobacco leaf purchasing, a TPC purchasing system and a running method thereof. The networked intelligent POS machine system for tobacco leaf purchasing comprises an embedded system, and a display and touch module, a printer, a communication module, a card reading module, an interface module and a power supply module which are connected with the embedded system. The networked intelligent POS machine system for tobacco leaf purchasing adopts the embedded system, takes an android system as an operation platform, is designed in an integrated manner, and has a high level of integration. Purchasing data can be transmitted through the network. The system is seamlessly connected with the National Bureau purchasing software of an invoicing host to complete data uploading and downloading. By using the android system as the operation platform, there is a large space for function expanding, and the system can be greatly compatible with different purchasing modes of different areas.