The disclosure discloses a method of tuning an antenna and a device. The method comprises: receiving a signal output from an amplifier, and performing, by a tuning network, primary tuning on the signal; determining whether a standing wave of the primary tuned signal exceeds a preconfigured threshold; if so, driving gradually the tuning network to obtain a preferred matching tuning network parameter; and tuning, according to the preferred matching tuning network parameter, the primary tuned signal, and transmitting the same by an antenna.