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发明授权
CN105753793B 芳甲酰脲偶联喹唑啉类化合物及其制备方法、药物组合物及药物用途 有权

芳甲酰脲偶联喹唑啉类化合物及其制备方法、药物组合物及药物用途
摘要：
本发明提供一种式(I)所示的芳甲酰脲偶联喹唑啉类化合物或其药学上可接受的盐，R2或R3之一为式(II)所示的基团；本发明还提供一种制备式(I)所示的芳甲酰脲偶联喹唑啉类化合物或其药学上可接受的盐及其中间体的方法，药物组合物，以及上述芳甲酰脲偶联喹唑啉类化合物或其药学上可接受的盐在制备涉及肿瘤相关的疾病的药物中的用途。本发明提供的芳甲酰脲偶联喹唑啉类化合物或其药学上可接受的盐能够用于治疗涉及肿瘤相关的疾病。
摘要（英）：

The invention provides an aroylurea coupled quinazoline type compound shown as in formula (I) or a pharmaceutically acceptable salt thereof, wherein one of R2 or R3 is a group shown as in formula (II); the invention also provides a method for preparing an aroylurea coupled quinazoline type compound shown in formula (I) or a pharmaceutically acceptable salt thereof and an intermediate of this compound, a pharmaceutical composition, and the uses of the aroylurea coupled quinazoline type compound or the pharmaceutically acceptable salt thereof in the preparation of pharmaceuticals for tumor related diseases.The aroylurea coupled quinazoline type compound or the pharmaceutically acceptable salt thereof provided herein can be used to treat tumor related diseases.

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