The embodiment of the invention provides an image compression method, an image reconstruction method, a device and a system, which relate to the technical field of display and aim at improving a compression ratio when an image signal is compressed while the image reconstruction quality is ensured. The image compression method comprises steps: a compressing end divides the image into a target area and a non target area; the image compression method uses a first sampling rate to sample a first image signal in the target area, and a first sampling image is obtained; the compressing end uses a second sampling rate to sample a second image signal in the non target area, and a second sampling image is obtained, wherein the second sampling rate is smaller than or equal to the first sampling rate; and the compression end sends the first sampling image and the second sampling image to a reconstruction end to enable the reconstruction end to restore the image according to the first sampling image and the second sampling image. The method can be applied to image compression and image reconstruction processes.