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发明公开
CN105777572A 一种阿戈美拉汀混晶的制备方法及其在片剂中的应用 无效 - 撤回

一种阿戈美拉汀混晶的制备方法及其在片剂中的应用
摘要：
本发明公开了一种阿戈美拉汀混晶的制作方法及其在片剂中的应用。所述阿戈美拉汀混晶的制备方法。所述阿戈美拉汀Ⅱ晶型与Ⅹ晶型混晶比例；所述阿戈美拉汀处方及工艺。利用本发明制备的阿戈美拉汀混晶能够较好地增加阿戈美拉汀片在不同介质中的溶出速率，从而提高药物的生物利用度。
摘要（英）：

The invention discloses a preparation method of an agomelatine mixed crystal and application thereof in tablets. According to the preparation method of the agomelatine mixed crystal, the mixing ratio of an agomelatine II crystal form and an X crystal form is shown as the specification. The invention also discloses an agomelatine prescription and a process. The agomelatine mixed crystal prepared by the method provided by the invention can well increase the dissolution rate of agomelatine tablets in different media, thus enhancing the drug bioavailability.

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