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发明公开
CN105777615A 4-吗啉代哌啶的制备方法 无效 - 驳回

4-吗啉代哌啶的制备方法
摘要：
本发明涉及一种药物中间体制备方法，具体涉及一种4?吗啉代哌啶的制备方法。本发明创造为将1?苄基?4?哌啶酮与吗啉进行反应制备得到4?(1?苄基哌啶?4?基)吗啉二盐酸，然后继续反应制备得到终产物4?吗啉代哌啶。本发明创造方法简便，产物收率和纯度高，反应条件温和安全性高，特别适合工业化生产。
摘要（英）：

The invention relates to a preparation method of a drug intermediate, in particular to a preparation method of 4-morpholino piperidine.The preparation method comprises the steps that 1-benzyl-4-piperidone and morpholine are reacted to prepare 4-(1-benzyl piperidine-4-base) morpholine dihydrochloride, then, the reaction continues to be performed, and the end product 4-morpholino piperidine is obtained.The method is easy and convenient, the product yield and purity are high, the reaction condition is mild and high in safety, and the method is particularly suitable for industrial production.

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