The invention provides a multi-functional safety device of a stereoscopic garage. The device comprises a fixation frame, a guide anti-falling base, a guide limiting servo frame, an anti-falling device and a travel switch, wherein the guide limiting servo frame and the anti-falling device are installed on the fixation frame; the fixation frame is installed on a middle-segment horizontal moving device; the guide anti-falling base is fixed on a lifting vehicle carrying plate; and when the lifting vehicle carrying plate ascends, the guide anti-falling base cooperates with the guide limiting servo frame, the guide limiting servo frame also cooperates with side beams, the anti-falling device cooperates with the guide anti-falling base, and the travel switch is installed on the guide limiting servo frame. The device disclosed by the invention has the advantages that functions of guiding, limiting, servo driving and falling prevention are integrated; all the functional structures are connected closely; the harmony degree is high; a space utilization rate is high; and because of a high degree of integration, accumulated errors are small, and position accuracy is high.