The invention discloses a novel grouting process applicable to pipe jacking construction of a desert region. Firstly, when a machine head of a pipe jacking machine tunnels towards a desert stratum, machine head synchronous grouting slurry is pressed and injected towards the outer side of a pipe in a 30m range of the rear side of the machine head of the pipe jacking machine, and a complete slurry sleeve is formed, wherein the grouting amount of the machine synchronous grouting slurry is 3-6 times as much as that of the volume of a machine tail gap; the grouting pressure is 0.5 gamma h-1.5 gamma h, gamma is the capacity of soil and h is the burying depth; after the slurry sleeve is formed, a jacking pipe is used for pressing and injecting linear following slurry replenishing slurry to the outer side of the pipe, so that the loss of the slurry sleeve is supplemented and lubrication and resistance reduction are realized; the linear slurry replenishing amount is 3-5 times as much as the volume of the machine tail gap; and the grouting pressure is 0.2MPa-0.4MPa. The machine head synchronous grouting is good for completely protecting a wall; the linear slurry replenishing is good for lubricating and reducing resistance; and the grouting amount and the grouting pressure are set, so that the effects of rapidly and accurately grouting to form the slurry sleeve, lubricating and reducing the resistance of the grouting slurry are guaranteed.