The invention discloses a system and a method for realizing asynchronous interaction mode communication in a cluster environment, which relate to the field of communication realization methods of an asynchronous interaction mode. When the system is initialized, application modules at two communication endpoints carry out AIM module registration; a request side AIM module perceives that a response side goes online, and adds an address of the response side; when a request side application module initiates a request, the request side AIM module sends a request message to the response side; a response side application module which receives the request message processes the request message, and returns an AIM response message to a corresponding request side; the request side receives the AIM response message and triggers a home terminal application module to process the response message; and when the request side AIM module perceives that one response side goes offline, the request side AIM module automatically deletes the address of the response side. The system and the method can realize asynchronous interaction mode communication in the cluster environment on the premise of satisfying communication requirements, the realization method is simplified, and the code development has low difficulty and small redundancy.