The invention belongs to the field of functional polymer nanomaterials, and particularly discloses an amphiphilic binary molecular brush polymer and pH responsive unimolecule nanomicelles constructed by the same.The polymer has the following general structural formula of A-g-(B-r-C), wherein g represents grafting, r represents random copolymerization, A represents a polymer main chain, B represents a pH responsive a macromolecule side chain, C represents a hydrophilic macromolecule side chain, and the side chain B and the side chain C are randomly grafted to the main chain A.The amphiphilic binary molecular brush polymer N,N-dimethylformamide solution is slowly added into water with the pH being 8 dropwise and stirred for 2 h to obtain the pH responsive unimolecule nanomicelles.The problem that traditional polymolecular micelles are disintegrated when the concentration is lower than critical micelle concentration or under the action of ionic strength and large shear force is solved, and micelle stability is improved.The particle size of the unimolecule nanomicelles can be adjusted according to length of the main chain, and therefore controllability of the micelle size is improved.