The invention relates to a cell model having undergone vicious transformation. A novel cell line having undergone vicious transformation is developed on the basis of human-derived normal cell for the first time in the invention. The cell line is screened out after long-term stimulation by low-concentration benzopyrene; and identification results show that the cell model has undergone vicious transformation. The cell line can be used as a cell model for research on pathogenic effect of benzopyrene or screening of drugs capable of inhibiting vicious transformation of cells.