The invention discloses a damage resisting tolerance high-strength aluminum alloy plate and a preparation method thereof. The damage resisting tolerance high-strength aluminum alloy plate includes the chemical components of, by mass, 0-0.08% of Si, 0-0.15% of Fe, 4.1-4.4% of Cu, 0.50-0.70% of Mn, 1.2%-1.4% of Mg, 0-0.10% of Cr, 0-0.15% of Zn, 0-0.15% of Ti, and the balance Al. The preparation method of the damage resisting tolerance high-strength aluminum alloy plate includes the steps of smelting, casting, two-step homogenization of tapping air cooling, surface milling, hot rolling, two-stage solution treatment, quenching, natural aging and the like. Compared with the standard product performance of the ordinary 2024T351 state, the yield strength of the plate is higher by 20 MPa or over, the elongation of the plate is higher by 33%, and the plate has quite good breaking tenacity and fatigue crack growth resistance.