The invention discloses a large-area fiber panel compacting mold and a manufacturing method, and is applied to the field of manufacturing of a fiber panel. According to the large-area fiber panel compacting mold and the manufacturing method, a large-area fiber panel blank is directly prepared by skipping the steps of preparing the large-area fiber panel blank first and then performing cutting, and the phase with highest difficulty, longest consumed time and greatest fund investment in a whole preparation process is avoided, such that technical innovation is realized, and the manufacturing cost is substantially decreased. The front surface and the back surface of each large-area fiber panel are each provided with a heat-conducting plate, such that the heat-conducting plates reach a specified temperature faster in a heating or cooling process. Contact type heat conduction is performed on cross sections of glass screen segments by taking high-temperature or low-temperature heat-conducting plates as new heat sources or heat absorbers, such that the heating time and the cooling time are shortened, and the processing efficiency is improved.