The invention relates to a method for determining explosion driving design indexes. The method comprises the steps of: selecting indexes which may influencing an explosion effect in explosion design; determining the weights of the selected indexes; and ordering the indexes according to the magnitudes of the weights, and selecting the plurality of indexes with the maximum weight as main indexes influencing the explosion effect in the explosion design. According to the invention, weight distribution is carried out on the plurality of selected influencing indexes by an analytic hierarchy method, the magnitudes of the weights are adjusted by means of consistency verification, and finally the plurality of indexes having the maximum influences on the explosion effect are screened out according to the magnitudes of the weights. The method provided by the invention is supported by theories and can also be applied practically, the indexes having the maximum influences on the explosion effect can be accurately determined, the influences of the indexes on explosion are fully and mainly considered in the explosion design, and the practical explosion construction effect is substantially improved.