The invention discloses a power driving circuit and a light emitting diode (LED) lamp tube. The power driving circuit comprises a first voltage input end, a second voltage input end, a first simulation lamp filament, a second simulation lamp filament, a high-pass circuit, a control circuit, an isolation circuit, a first rectification circuit, a second rectification circuit and a DC conversion filter circuit, wherein the above circuits are connected with one another to form the power driving circuit. The power driving circuit can be applied to an AC mains supply and is simultaneously compatible with an electronic ballast; with the design of the high-pass circuit, the control circuit and the isolation circuit, the power driving circuit conforms to leakage current test and voltage resistant test in safety regulation; and on the other hand, the LED lamp tube comprising the power driving circuit can be compatible with the electronic ballast and also conforms to the leakage current test and voltage resistant test in safety regulation, and the compatibility of various types of electronic ballasts is further improved.