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发明授权
CN105814048B 作为TNF活性调节剂的稠合三环苯并咪唑衍生物 有权

作为TNF活性调节剂的稠合三环苯并咪唑衍生物
摘要：
一系列三环苯并咪唑衍生物，尤其是二氢‑1H‑咪唑并[1,2‑a]苯并咪唑、二氢‑1H‑吡咯并[1,2‑a]苯并咪唑、二氢‑1H‑吡嗪并[1,2‑a]苯并咪唑、二氢‑1H‑[1,4]嗪并[4,3‑a]苯并咪唑和二氢噻唑并[3,4‑a]苯并咪唑及其类似物，是有效的人TNFα活性调节剂，因此在多种人疾病的治疗和/或预防中具有益处，所述人疾病包括自身免疫性障碍和炎症性障碍；神经学和神经变性障碍；疼痛和伤害感受性障碍；心血管障碍；代谢障碍；眼障碍；和肿瘤学障碍。
摘要（英）：

A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

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