The invention discloses a shoe middle part, a shoe workpiece, a shoe and a manufacturing method of the shoe. The shoe is characterized by comprising a shoe outsole, the shoe middle part and a shoe upper part, wherein the middle region on the shoe middle part is covered with the shoe outsole and adheres to the shoe outsole to form an insole, an upper is formed in the skirt region on the shoe middle part, and an upper binding opening and the middle upper part are sewn together to form a vamp. The structure is simple, wear is comfortable, and the shoe is convenient to manufacture and process. The manufacturing method of the shoe mainly has the advantages that innersole design is avoided, the insole and an innersole are combined, then the vamp is processed, finally the insole, the innersole and the vamp are combined and sewn together, the structure is simple, the shoe is durable in wear, and processing is convenient.