The invention relates to a dynamic electrostimulation integrated control system and method of muscle groups. The system comprises a pressure sensor and a dynamic electrostimulation instrument; the dynamic electrostimulation instrument includes multiple stimulation channels, and each stimulation channel includes a pair of stimulation electrodes that can be applied to the surface of skin; the dynamic electrostimulation instrument also includes a stimulation parameter modulation unit, and stimulation parameters include stimulation waveform, stimulation intensity, stimulation frequency, stimulation wave width, waiting time before stimulation and stimulation continuous time. The method comprises that different parts are worn or fixed, the stimulation parameters are set, stimulation is started, and stimulation is completed. According to the invention, coordinated electrostimualtion can be realized for the multiple muscle groups of lower limbs, and patients who have a hemiplegic gait due to partially insufficient muscle force caused by diseases can be helped to make complete walking motions.