The invention discloses a pipeline fixation mechanism based on enhancing operational convenience. The mechanism comprises a baseplate, wherein rollers are disposed on the bottom of the baseplate; two side plates are symmetrically disposed on the baseplate; at least two threaded through holes are formed in the side plates; screw rods are disposed in the threaded through holes; one end of each screw rod is connected to an arc clamping plate, and the arc clamping plates are disposed on the inner side of the side pates; and the other end of the screw rod is in a hinged connection with a supporting rod, and multiple clamping grooves matched with the supporting rods are formed in the outer side walls of the side plates. The mechanism disclosed by the invention is characterized in that a petroleum pipeline is clamped by the side plates and the arc clamping plates which are mutually matched; the petroleum pipeline is placed and taken out through adjustment of positions of the screw rods; and then the screw rods are fixed through cooperation between the supporting rods and the clamping grooves. In this way, the mechanism disclosed by the invention can tightly clamp the petroleum pipeline; and operations are convenient and reliable.