The present invention discloses a surgical stapler. The surgical stapler includes a first handle part, a second handle part, and a adjustment mechanism; the first handle part includes a staple cartridge component and a drive assembly, and the second handle part includes a staple abutting seat; a locking mechanism is arranged on the first handle part or/and the second handle part; the first handle part and the second handle part may rotate via the rotation shaft, and lock in a longitudinal direction; the adjustment mechanism is located between the first handle part and the second handle part; the adjustment mechanism may make, by means of adjustment, the second handle part rotate relative to the first handle part via the rotation shaft thereon. The surgical stapler provided by the present invention may make, by means of the adjustment mechanism at the proximal end of the handle, the thickness of the tissue after clamping reach the same at the proximal and distal ends, so as to improve the formation rate of the suturing staple, and reduce the bleeding of the suturing staple, anastomotic leakage and the like.