The invention discloses an unmanned aerial vehicle integrated defense system and a method. The unmanned aerial vehicle integrated defense system comprises a reconnaissance equipment unit, an interference equipment unit and a control unit, and is characterized in that the reconnaissance equipment unit integrates a radar reconnaissance technology, a photoelectric reconnaissance technology and a radio reconnaissance technology to carry out monitoring on a designated area so as to recognize an unmanned aerial vehicle and acquire movement and position information and instruction and image transmission information of the unmanned aerial vehicle and azimuth information of a manipulator of the unmanned aerial vehicle; and the control unit realizes interference for instruction signals, navigation signals and image transmission signals of the unmanned aerial vehicle through the interference equipment unit according to the acquired information. The unmanned aerial vehicle integrated defense system increases electronic reconnaissance on the basis of integrating the radar, photoelectric/infrared reconnaissance and electronic interference technologies so as to carry out reconnaissance analysis on wireless signals of the unmanned aerial vehicle, is applied to guidance interference, and improves the interference effectiveness and the efficiency; and meanwhile, the unmanned aerial vehicle integrated defense system can carry out remote positioning on the manipulator of the unmanned aerial vehicle, provides capture guidance for a law-enforcing department while realizing unmanned aerial vehicle defense, and improves the crime committing cost of unmanned aerial vehicle crime committing.